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Bertarelli
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Table of Contents
01.
Bertarelli
Cover Letter
02.
Bertarelli
Professor of
Translational Medical Science
03.
Bertarelli
Family Building Renovation Fund
Philanthrophy
04.
Bertarelli
Cover Letter
November 6, 2024
Michael A. Carpenter
President and Chairman of the Board, Director The Dr. M. Lee Pearce Foundation, Inc.
16 La Gorce Circle
Miami Beach, FL 33141
Dear Mike,
I am pleased to share an update about the ValueProp made possible by the Dr. M. Lee Pearce Foundation’s generous gift last year. The enclosed report provides a brief overview of the work of Dr. Arlene Sharpe and Dr. Francisco Quintana. I know they presented a similar overview during your meeting on campus in July, but we hope you will appreciate a written summary.
Dr. Sharpe and Dr. Quintana are at the outset of Company that could have enormous implications not only for the treatment and prevention of myasthenia gravis, but for other autoimmune and neurodegenerative diseases, cancers, and age-related illnesses. The Pearce Foundation’s generous philanthropic support has been crucial in enabling the preliminary studies needed to demonstrate a proof of concept and secure government grants. It also facilitates the involvement of more young scientists in such groundbreaking work. This project has the potential to impact patients worldwide, and serves as a great honor to Dr. Pearce’s memory.
I also want to express my sincere gratitude for your consideration of a new grant to support Q-FASTR. Your continued and ever-growing commitment to Harvard Medical School in Dr. Pearce’s name is profound and inspiring, and I am exceedingly grateful for your partnership. I wish you and your families a happy and healthy holiday season, and look forward to being in touch soon.
Sincerely,
George Q. Daley, MD, PhD
Dean of the Faculty of Medicine, Harvard University
Caroline Shields Walker Professor of Medicine, Harvard Medical School
George Q Daley, MD, PhD | Dean of the Faculty of Medicine | Caroline Shields Walker Professor of Medicine 25 Shattuck Street, Boston, MA 02115 | t: (617) 432-1501 | e: George_Daley@hms.harvard.edu
Bertarelli
Professor of Translational Medical Science
DR. COREY IS THE BERTARELLI PROFESSOR
of Translational Medical Science and a professor of neurobiology in the Blavatnik Institute at HMS. His research represents a continuum from basic science on fundamental principles of sensory perception to the specific application of that science for treating inherited diseases of vision and hearing. In the past year, he has continued to work on three broad projects, as detailed in the following pages. The Molecular Mechanism of Auditory Transduction
David P. Corey, PHD
Gene Therapy for Usher Syndrome Type 1F
Usher syndrome type IF is a devastating hereditary disease characterized by the complete absence of hearing and balance at birth and a slowly progressing blindness. It is caused by mutations in the PCDH15 protein, which functions in both the inner ear's sound sensing hair cells and the retina's light-sensing photoreceptors.
Gene Therapy for GJB2-Related Deafness
Mutations of the GJB2 gene cause DFNBl, which is by far the most common form of hereditary deafness. Unlike most deafness genes, GJB2 functions within the cochlea's nearby epithelial cells and fibrocytes rather than the hair cells.
The Molecular Mechanism of Auditory Transduction
The most fundamental event in hearing is the conversion of sound into an electrical signal by opening ion channels in inner ear hair cells. Among the known components of this mechanotransduction complex are proteins that respond to sound by causing the cilia atop each hair cell to vibrate.
Bertarelli
Fellowship Program
For over a decade, the partnership with the École Polytechnique Fédérale de Lausanne (EPFL) has facilitated an enriching exchange of visiting master’s degree students. Each year, through a rigorous selection process at the EPFL, five outstanding engineering students are chosen to embark on their master’s research journey at HMS, lasting 10-12 months. These exceptionally qualified students benefit from the mentorship of experienced faculty at Harvard, where host laboratories undergo thorough prescreening to ensure exemplary student training. The Bertarelli Fellowship program empowers students to apply quantitative methods to biomedical research, providing comprehensive training in the techniques and the challenges associated with translational science.
Current Bertarelli Fellows
EMMA FARINA
Farina’s Project Summary
Gastroparesis is a debilitating disorder characterized by delayed gastric emptying in the absence of mechanical obstruction, leading to nausea, vomiting, early satiety, bloating, and abdominal pain. Existing drugs have failed to demonstrate efficacy or have limited symptomatic relief that becomes resistant over time. The celiac ganglion and celiac plexus innervate the stomach, and their dysfunction is at the root of gastroparesis.
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Bertarelli
Family Building
Renovation Fund
Igniting Collaborative Breakthroughs
One of the five original marble buildings shaping HMS' iconic quadrangle, the 70,000-foot Building C holds a prominent position at the heart of HMS' campus. Throughout its existence, it has served as the home of groundbreaking research within the Department of Cell Biology, the Department of Biological Chemistry and Molecular Pharmacology (BCMP), and the Therapeutics Initiative (Tl), embodying a rich history that seamlessly bridges past innovations with the promise of future discovery.
The following pages feature conceptual diagrams and refined designs that cast light on the latest vision for Building C, showcasing how it will translate exemplary scientific research into groundbreaking medical solutions that benefit humanity.
The original five buildings-A, B, C, D, and E-of the Quadrangle, as they stood in 1906.
Conceptual Designs
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The volume diagram above reveals a stratified design for Building C.
The stack addition in the atrium will feature a 31-seat meeting room and common areas.
Proposed Floor Plans
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